Analysis and Management of Potential Drug Interactions in Patients With Diabetes Mellitus and Comorbidities at Hospital X
DOI:
https://doi.org/10.57235/jetish.v5i2.9241Keywords:
Comorbidity, Diabetes Mellitus, Drug Interaction, Interaction Management, PolypharmacyAbstract
Diabetes mellitus is a chronic metabolic disease that is frequently accompanied by comorbidities, requiring the use of multiple medications (polypharmacy). This increases the risk of potential drug interactions that may reduce therapeutic effectiveness and increase the incidence of adverse drug reactions. This study aimed to analyze potential drug interactions in patients with diabetes mellitus and comorbidities based on severity, interaction mechanisms, and recommended drug interaction management strategies. This descriptive observational study employed a retrospective approach using secondary data obtained from the medical records of patients with diabetes mellitus and comorbidities at Hospital X during the January–December 2025 period. A total of 93 patients who met the inclusion criteria were included in the study. Potential drug interactions were analyzed using the Drugs.com Drug Interaction Checker. The results identified 154 potential drug interactions. Based on severity, moderate interactions were the most common, accounting for 123 cases (80%), followed by minor interactions with 28 cases (18%) and major interactions with 3 cases (2%). Based on interaction mechanisms, pharmacodynamic interactions were more frequent, with 103 cases (67%), than pharmacokinetic interactions, with 51 cases (33%). Recommended drug interaction management strategies included therapeutic monitoring, dose adjustment, modification of drug administration time, and drug substitution when necessary. These findings highlight the importance of identifying and managing potential drug interactions to improve medication safety and therapeutic effectiveness in patients with diabetes mellitus and comorbidities.
Downloads
References
American Diabetes Association. (2025). Standards of care in diabetes. Diabetes Care, 48(1), S1–S350.
Aripin, A., Ismaya, N. A., Pratiwi, R. D., Indah, F. P. S., & Azzahra, E. (2024). Evaluasi Penggunaan Obat Antidiabetes Pada Pasien Diabetes Mellitus Dan Terdapat Hipertensi Di Rumah Sakit Uin Syarif Hidayatullah. Edu Masda Journal, 8(1), 72. https://doi.org/10.52118/edumasda.v8i1.214
Artiany, S., & Gamayana Trimawang Aji, Y. (2021). Gambaran Komorbid pada Pasien Hemodialisis di Rumah Sakit Angkatan Udara (RSAU) drEsnawan Antariksa. Jurnal Keperawatan Cikini, 2(2), 1–6. https://doi.org/10.55644/jkc.v2i2.57
Fariansiska, N. P., & Mayasari, S. (2024). Identification Of Oral Antidiabetic Drug Interactions In Polypharmacy Prescription Of Patients Diabetes Mellitus At Jember Hospital. Jurnal EduHealth, 15(03), 2024. https://doi.org/10.54209/eduhealth.v15i03
International Diabetes Federation. (2025). IDF Diabetes Atlas (11th ed.). International Diabetes Federation.
Murray, A. D., & Khezrian, M. (2020). An overview of prevalence, determinants and health outcomes of polypharmacy. British. Journal of Clinical Pharmacology, 86(10), 1812–1818. https://doi.org/https://doi.org/10.1111/bcp.14305
Nabila Faradita Istutilah, Rina Kriswiatiny, Dalfian, T. P. (2025). Pengaruh Jenis Kelamin Terhadap Prevalensi Non-Proliferative dan Proliferative Retinopati Diabetik Pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Bintang Amin. Jurnal Medika Malahayati, 9(3), 538–545.
Novitasari, R., Pondawinata, M., & Permatasari, J. (2025). Korelasi Depresi Terhadap Kepatuhan Pengobatan Pasien Diabetes Melitus Tipe II Di Wilayah Kerja Puskesmas Pakuan Baru Jambi. Indonesian Journal of Pharma Science, 7(1), 9–15. https://online-journal.unja.ac.id/ijps/article/view/35124
Permatasari, J., Mitra, A. D., & Ilmi, M. (2024). Polifarmasi Pasien Hipertensi Rawat Jalan Di Rumah Sakit X Di Kabupaten Batang Hari Periode Januari - Maret Tahun 2023. 5, 23–28.
Rasdianah, N., & Gani, A. S. W. (2021). Interaksi Obat Pada Pasien Diabetes Melitus Tipe 2 Dengan Penyakit Penyerta Di Rumah Sakit Otanaha Kota Gorontalo. Indonesian Journal of Pharmaceutical Education, 1(1), 40–46. https://doi.org/10.37311/ijpe.v1i1.9953
Refdanita, & Sukmaningsih, V. (2021). Potensi interaksi obat pasien diabetes melitus Tipe-2 dengan Hipertensi di Rumah Sakit “ X ” Periode 2019. Jurnal Sainstech Farma, 14(1), 50–51.
Soleh, A. A. P. M., & Putri, L. I. (2023). Identifikasi Drug Related Problems (DRPs) Pada Pasien Diabetes Melitus Tipe 2 Di Rawat Inap. Journals Of Ners Community, 13(2), 346–352.
Susanti, N., Raniah, S., Sari, N. C., & Agustin, A. M. (2024). Kejadian Penyakit Diabetes Melitus Di Upt Puskesmas Stabat. Jurnal Kesehatan Masyarakat, 8, 6355–6361.
Ulya, N., Zanetha, A., Sibuea, E., Purba, S. S., Ikka, A., & Herbawani, C. K. (2023). Analisis Faktor Risiko Diabetes pada Remaja di Indonesia. Journal Volume 4, Nomor 3, September 2023, 4(September), 2332–2341.
Utami, P. R., & Octavia, D. R. (2022). Study of potential interactions of oral antidiabetic drugs in patients with type 2 diabetes mellitus with comorbidities: A retrospective study. Pharmacy Education, 22(2), 200–206. https://doi.org/10.46542/pe.2022.222.200206
World Health Organization. (2024). Diabetes. https://www.who.int/news-room/fact-sheets/detail/diabetes
Downloads
Published
Issue
Section
Citation Check
License
Copyright (c) 2026 Jelly Permatasari, Indri Meirista, Juwani Legistria
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors are copyright holders and maintain author rights in accordance with the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) or comparable license. While holding these rights, authors grant the JETISH: Journal of Education Technology Information Social Sciences and Health (publisher of JETISH) a non-exclusive right to the first publication of their articles, including abstracts. This enables us to ensure full copyright protection and to disseminate the article to the widest possible readership in electronic format. Authors are themselves responsible for obtaining permission to reproduce copyright material from other sources.
